The prevalence of venous leg ulcers (VLUs) differs between 1.5% and 3% in the general population. The challenge in treating VLUs is common recurrence. Moreover, VLUs can be resistant to healing, despite appropriate treatment. In these cases, advanced wound therapies should be considered. The number of new technologies, applied in VLUs treatment, has increased in the last years. These therapies include biophysical interventions such as ultrasound therapy, electrical stimulations, electromagnetic therapy, or phototherapy. Furthermore, stem cell therapies, biologic skin equivalents, platelet-rich plasma therapy, oxygen therapies, anti-TNF therapy, or negative pressure wound therapy are advanced venous ulcer therapeutic methods that may support the standard of care. Medical devices, such as a muscle pump activator, or intermittent pneumatic compression device, may be especially useful for specific subgroups of patients suffering from VLUs. Some of the above-mentioned technologies require broader evidence of clinical efficacy and are still considered experimental therapies in dermatology.
Introduction. Adult-onset Still's disease is a systemic inflammatory disease characterized by fever, arthritis, lymphadenopathy, splenomegaly, inflammation of internal organs, and skin lesions. Objective. Presentation of a rare, systemic inflammatory disease associated with cutaneous manifestations. Case report. A 52-year-old woman was admitted to the Department of Dermatology with erythematous skin lesions associated with with intermittent itch. For a year before hospital admission, the skin lesions recurrently appeared in the late afternoon and resolved completely at night. Conclusions. The cutaneous lesions in adult-onset Still's disease have a tendency tends to develop and disappear in episodes associated with fever. The typical cutaneous manifestations include erythematous or erythematopapular lesions, usually with a salmon-like tint. However, the disease may also be associated with an atypical cutaneous presentation, which should be taken into consideration to ensure early diagnosis and effective treatment to prevent joint damage. streszczenie Wprowadzenie. Choroba Stilla u dorosłych jest układową chorobą zapalną cechującą się gorączką, zapaleniem stawów, powiększeniem węzłów chłonnych i śledziony, stanami zapalnymi narządów wewnętrznych oraz zmianami skórnymi. Cel pracy. Przedstawienie przypadku choroby Stilla, rzadkiej układowej choroby zapalnej przebiegającej z objawami skórnymi. Opis przypadku. Kobieta 52-letnia została przyjęta do Kliniki Dermatologii w celu diagnostyki zmian rumieniowych z okresowo występującym świądem. Od roku, przed przyjęciem do Kliniki, zmiany skórne pojawiały się w późnych godzinach popołudniowych i ustępowały całkowicie w nocy. Wnioski. Osutka w przebiegu choroby Stilla u dorosłych występuje u około 90% pacjentów. Pojawia się i ustępuje wraz z występującą epizodycznie gorączką. Typowe zmiany skórne mają postać plam rumieniowych lub zmian rumieniowo-grudkowych o charakterystycznym, łososiowym zabarwieniu. W przebiegu choroby Stilla mogą również wystąpić nietypowe objawy skórne, co utrudnia postawienie właściwej
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