Background. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥50%)). Results. Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P = 0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P = 0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30–0.92), P = 0.038, among patients with significant stenosis. Conclusions. Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.

BackgroundAbnormalities in lipids with increased serum concentration of LDL‐C are risk factors for coronary artery disease (CAD), and atherosclerosis. The aim of this study was to investigate the association between serum LDL‐cholesterol, and significant coronary artery stenosis with well‐known genetic variants in chromosomal locus 1p13.3 among CAD patients with and without significant coronary artery stenosis [case and control groups] respectively.MethodsBlood was drawn from a total of 178 patients. Genotyping for the variants rs599839, rs646776 and rs4970834, were performed by the 5’ nuclease test using TaqMan assay.ResultsThe HDL‐C level of rs599839 was [12.01± 3.9 mM vs. 3.46± 1.45 mM] for GG vs. AA+AG using the recessive genetic model with p value=0.006. Using the additive model, rs64776 variant had a significantly higher triglycerides levels [7.76±2.25 vs. 1.74±0.15 mM] for AA vs. GG respectively with p value=0.031. No significant difference was observed for LDL‐C and cholesterol among genotypes of all variants using different genetic models. The rs599839 variant had a significant association with the severity of coronary stenosis using additive model. The OR was 2.7 times among patients with significant stenosis (p =0.04). Stepwise regression analysis revealed that the following independent variables have a statistically significant effect on LDL‐C level; BMI, diabetes, TC, TG, HDL‐C, and anti‐lipidemic treatment in presence of rs59839 and rs646776 and rs4970834.ConclusionIn summary, polymorphism rs646776 and of rs599839 were significantly associated with HLD‐C and triglycerides levels, but not with LDL‐C. In addition the variant rs599839 had a significant association with atherosclerotic lesion in coronary vessels.