<p>Multiple input-multiple output (MIMO) is a multipath diversity exploring approach which is emerged with orthogonal frequency division multiplexing (OFDM) to produce MIMO-OFDM that is widely used in wireless communications. This paper presents a discrete Hart-ley transform (DHT) precoded MIMO-OFDM system over multipath frequency-selective fading channel with large-size quadrature amplitude modulation (16-QAM, 64-QAM and 256-QAM). A mathematical models for the BER and channel capacity over mutlipath fading channels are also derived in this paper. Average Bit-error-rate (BER) and channel capacity of the presented system is considered and compared with that of the traditional MIMO-OFDM. Simulation results shows that the transmission performance and channel capacity of the proposed schemes is better than that of the traditional MIMO-OFDM without a pre-coder.</p>