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Sixty preparations of normal human serum albumin which had been in storage longer than the time legally permissible for suitability for clinical administration were examined. Chemical and physical measurements showed the albumins to meet all of the minimum requirements of the Division of Biologies Standards for clinically acceptable albumin. After pooling and sterilizing refiltration through 0.2 μ Millipore pads, the albumins were found acceptable for clinical use. Improvement in the clinical status of patients receiving the aged albumin compared favorably with the expected results from conventional albumin infusion. There was no evidence of adverse reactions.