HIV-1 protease is a key enzyme in the maturation process of HIV protein. HIV-1 PIs is an important class of drug to inhibit HIV infection and has an important effect...

Since the first report of bifunctional sulfonamide organocatalysts in 2004, these chiral compounds have proven to be a reliable hydrogen-bonding catalyst and have been wildly employed in asymmetric organocatalysis due to its strong acidity and self-aggregation-free property. Herein, we review the application of bifunctional sulfonamide as hydrogenbonding catalyst after 2011, and our highlights will cover asymmetric process including aldol reaction, Michael addition, Mannich reaction, desymmetrization and cyclization.