For solving the crack in crankshaft, laser cladding remanufacturing was involved. There were three key points about laser cladding remanufacturing discussed in this paper.The three key points included process flow , process environment and laser cladding materials selection . Using the ANSYS analysis software, the simulated analysis of the temperature field , stress field and the residual stress of the three kinds of cladding layer have been carried on, the best cladding materials for single-throw crankshaft crack of base material 45# is determined by studying the repaired results about Iron-based,Cobalt-based,Nickel-based self-fluxing alloy powder cladding materials.