A 720-channel, 8-bit source driver has been developed for high resolution and high refresh-rate applications. A source synchronous point-to-point interface has been adopted. The timing relationship between the received clock and the received data is calibrated and configured in the timing controller (TCON). This simplifies the implementation of the source driver as the sensitive DLL or CDR circuits are not required in the source driver. The source driver is implemented in a 0.15μm 1.8V/16.5V high-voltage process. The achieved data rate is 2.5Gbps. It is applicable to a 240Hz FHD panel or a 120Hz 4K2K panel. Author Keywordssource driver; point-to-point interface; chained clock; half-supply output buffer.

Aim: A meta-analysis was conducted to assess the application of circulating cell-free DNA (cfDNA) in non-small-cell lung carcinoma (NSCLC) screening, EGFR and KRAS mutation detection. Materials & methods: A comprehensive literature search was conducted. The summary sensitivity and specificity for cfDNA in NSCLC diagnosis, EGFR and KRAS mutation detection were calculated. Results: The sensitivity and specificity for NSCLC diagnosis, EGFR and KRAS mutation detection were 0.80 (95% CI: 0.72–0.87) and 0.81 (95% CI: 0.68–0.91), 0.780 (95% CI: 0.711–0.853) and 0.962 (95% CI: 0.942–0.984), 0.628 (95% CI: 0.244–0.919) and 0.959 (95% CI: 0.932–0.998), respectively. Conclusion: cfDNA was a minimally invasive approach for NSCLC diagnosis, but its clinical utility warranted more future investigations because of the suboptimal sensitivity.