In a parallel time-interleaved data sampling system, timing and amplitude mismatches of this structure degrade the performance of the whole ADC system. In this paper, an adaptive blind synthesis calibration algorithm is proposed, which could estimate the timing, gain and offset errors simultaneously, and calibrate automatically.With no need of an extra calibration signal and redesign, it could efficiently and dynamically track the changes of mismatches due to aging or temperature variation. A fractional delay filter is developed to adjust the timing mismatch, which simplifies the design and decreases the cost. Computer simulations are also included to demonstrate the effectiveness of the proposed method.

Genotype-phenotype associations in neurofibromatosis type 1 (NF1): An increased risk of tumor complications in patients with NF1 splice-site mutations? Hum Genomics 2012;6:12.

Background. Human Schlafen 5 (SLFN5) is reported to inhibit or promote the proliferation of several specific types of cancer cells by our lab and other researchers. We are curious about its implications in lung adenocarcinoma (LUAC), a malignant tumor with a high incidence rate and high mortality. Method. Lentiviral stable transfections of SLFN5-specific shRNA for knockdown and SLFN5 full-length coding sequence for overexpression were performed in LUAC cell for proliferation analysis in vitro and in vivo in nude mice. Clinical LUAC samples were collected for immunohistochemical analysis of SLFN5 protein levels. Results. We found that knockdown of endogenous SLFN5 upregulates cancer cell proliferation while inhibiting apoptosis. Besides, SLFN5 inhibition on proliferation was also observed in a nude mouse xenograft model. In contrast, overexpression of exogenous SLFN5 inhibited cell proliferation in vitro and in vivo and promoted apoptosis. As to the signaling pathway, we found phosphatase and tensin homolog on chromosome 10 (PTEN) was positively regulated by SLFN5, while its downstream signaling pathway AKT/mammalian target of rapamycin (mTOR) was inhibited. Moreover, compared with adjacent normal tissues, SLFN5 protein levels were markedly decreased in lung adenocarcinoma tissues. In conclusion, these suggest that human SLFN5 plays inhibitory roles in LUAC progression through the PTEN/PI3K/AKT/mTOR pathway, providing a potential target for developing drugs for lung cancer therapy in the future.

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Time interleaving is one of the most efficient techniques employed in high-speed sampling systems. However, the frequency response mismatch among different channels will create distortion tones that degrade the system performance. In this paper, a self-adaptive frequency response mismatch compensation method is presented, where the design of compensation filter is optimized with a self-adapting strategy. This digital postprocessing technique realizes the compensation of frequency response effectively and also the increase of the digital bandwidth of the acquisition system. MATLAB-based simulation and an actual two-channel acquisition system test verify the effectiveness of the algorithm.