This work was carried out in collaboration between all authors.Author MEGF was the principal investigator, designed the study, conducted the data analysis and wrote of the paper. Author M-LDH oversaw the laboratory measurements and performed the statistical analysis. Authors HV, CM and RG were the study neurologists, oversaw patient care and assisted with interpreting the results, Author EN classify the participants for the group control. Authors LB and MR assisted with interpreting the results.All authors read and approved the final manuscript.