No abstract

The carcinogenicity of 1-(5-nitro-2-thiazolyl)-2-imidazolidinone (niridazole), a widely used schistosomicide, was examined in Swiss mice and Syrian golden hamsters. Schistosoma mansoni infection was evaluated as a cofactor. High incidences of drug-related neoplasms of the forestomach, lungs, mammary glands, urinary tract, and ovaries were found in mice, and tumors of the forestomach and urinary tract were found in hamsters. Infection with schistosomes had no apparent influence on tumor incidence. The results indicated a need for reevaluation of the possible carcinogenicity of this drug in man and suggested that care should be taken during its clinical use.

Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. No tumors attributable to treatment were observed in hamsters. In infected mice, the overall incidence of hepatomas and hepatocellular carcinomas increased from 3.4% in untreated mice to 10.6% in those treated with hycanthone. Non-infected control mice developed 0.8% of these tumors compared to 10.2% in mice treated with hycanthone. Despite the use of high dose levels of hycanthone, statistical significance was attained only with non-infected female mice injected intraperitoneally and intramuscularly with hycanthone and then only at confidence levels of 92 and 95% respectively.

Diğer taraftan, E. granulosus'un tenya devresi ev köpeklerinde, kurt, çakal, dingo ve cayot gibi hayvanlarda olgunlaşmaktadır.Mamafih, bu parazitler ev kedilerinin ve kırmızı tilkilerin barsakların-da yaşayabilmekle beraber yumurta produksiyonu devresine kadar gelişmernek tedi i'ler.

As a part of a series of studies on the therapy and on the prophylaxis of Boyine theilariasis, a clinico-pathologic investigation was undertaken separatcly on four of 7-8-month-old Holstein-friesian bull calvcs grown in a reportedly theileriasis free area in Turkey.The clinical signs, post mor te m and following histopathologiea! findings obtained form the biopsy or necropsy specimens were discussed in detail and some were illustrated in histopa thological microphotogra phes.