This study aimed at analyzing the relation between ABO blood group with three pregnancy complications that frequently occur in Indonesia (hyperemesis gravidarum, anemia, and preeclampsia). The sample was all the pregnant women recorded in the medical record in RSKDIA Pertiwi Makassar, Makassar Baji Labuang Hospital and Health Center-Kassi Kassi Makassar in 2013. Inclusion criteria for this study included maternal age 20-35 years, gestational age of over 28 weeks, domiciled in Makassar City, signed the informed consent form to participate in this research. Exclusion criteria included a history of blood disorder disease. ABO blood group was assessed by standard procedures using agglutination technique. There is no significant association between ABO blood group and the incidence of hyperemesis gravidarum (p> 0.05). There is no significant association between ABO blood group and the Gestational anemia incidence (p> 0.05). There is significant association between ABO blood group and the preeclampsia incidence (p < 0.05). In conclusion, there is a relationship between ABO blood group and the incidence of preeclampsia in pregnant women. Therefore, pregnant women need to go through the blood group screening from the beginning of pregnancy.