The fabrication of polymeric micro/nanofibers is gaining attention due to their use in an array of applications including tissue engineering scaffolds, nanosensors, and fiber-reinforced composites. Despite their versatile nature, polymeric fibers are widely underutilized due to the lack of reliable, large-scale production techniques. Upon the discovery of centrifugal spinning and, recently, pressurized gyration techniques, new research directions have emerged. Here, we report a comprehensive study detailing the optimal conditions to significantly improve the morphology, homogeneity, and yield of fibers of varying diameters. A series of polymeric fibers was created using a 21 wt. % solution of polyethylene oxide in distilled water and the fluid behavior was monitored inside a transparent reservoir using a high-speed camera. Fabrication of the fibers took less than 1 s. Using centrifugal spinning, we studied the formation of the fibers at three different rotational speeds, and for pressurized gyration, one rotational speed was studied with three different nitrogen gas pressures. Using the pressurized gyration technique at a gas pressure of 0.3 MPa, there was significant improvement in the production yield of the fibers. We found a strong correlation between the variation of pressure and the rate of the solution leaving the reservoir with the improved morphology of the fibers. The use of reduced power techniques, like centrifugal spinning and pressured gyration, to yield high-quality nonwoven nanofibers and microfibers in large quantities is important due to their use in rapidly expanding markets.

Purpose – This paper aims to investigate the relationship between improvements in information quality and the benefits and performance of e-government organizations. As information quality is multi-dimensional measure, it is very crucial to determine what aspects of it are critical to organizations to help them to devise effective information quality improvement strategies. These strategies are potentially capable of changing government organizational structures and business processes. It examines the nature, direction and strength of the connections between information quality and the success of e-government initiatives. A conceptual model by means of which organizations performance and information quality research can be viewed is proposed and validated in Kuwait. Design/methodology/approach – The study used a quantitative methodology to investigate the causal paths. A cross-sectional survey was completed by 268 employees positioned in the Kuwait Government ministries. Each of the main effect hypotheses was analyzed using stepwise multiple regression with stepwise selection. Findings – It was found that the relationships between information quality and strategic benefits along with institutional value were in upright agreement. Our statistical analysis highlighted that improvement in different aspects of information quality can lead to a better organizational image. Specifically, usability and usefulness attributes of information quality came on the top of the key influencers on both strategic benefits and institutional value. Originality/value – This is the first study which adequately covers the relationships between information quality and organizations performance in Kuwait. Based on our evaluation, the authors propose a conceptual model to assist in studying the effects of information quality improvement on e-government benefits and performance.

The combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide, which also exhibit the strongest anti-inflammatory action among oral antidiabetic drugs, were loaded into chitosan/gelatin/polycaprolactone (PCL) by electrospinning and polyvinyl pyrrolidone (PVP)/PCL composite nanofibrous scaffolds by pressurized gyration to compare the diabetic wound healing effect. The combination therapies significantly accelerated diabetic wound healing in type-1 diabetic rats and organized densely packed collagen fibers in the dermis, it also showed better regeneration of the dermis and epidermis than single drug-loaded scaffolds with less inflammatory cell infiltration and edema. The formation of the hair follicles started in 14 days only in the combination therapy and lower proinflammatory cytokine levels were observed compared to single drug-loaded treatment groups. The combination therapy increased the wettability and hydrophilicity of scaffolds, demonstrated sustained drug release over 14 days, has high tensile strength and suitable cytocompatibility on L929 (mouse fibroblast) cell and created a suitable area for the proliferation of fibroblast cells. Consequently, the application of metformin and pioglitazone-loaded chitosan/gelatin/PCL nanofibrous scaffolds to a diabetic wound area offer high bioavailability, fewer systemic side effects, and reduced frequency of dosage and amount of drug.