Purpose: This study was conducted to evaluate the applicability of ginseng berry in cosmetics. Methods: Ethanol extract of ginseng berry was analyzed using gas chromatography-mass spectrometry (GC-MS). 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging was used to determine the antioxidant activity, total polyphenol, and flavonoid content. Cell viability (MTT assay) confirmation was conducted to determine the toxicity, while the anti-inflammatory effect was investigated by measuring the inhibition of nitric oxide (NO) production. Results: The total polyphenol and flavonoid contents were 152±12.4 μg/mL and 50.16±1.48 μg/mL, respectively. DPPH scavenging activity in the extract with a concentration of 0.25 mg/mL increased to 59.21±4.20%, 0.5 mg/mL to 69.27±2.38%, and 1 mg/mL to 89.30±1.25%. Cell viability evaluation showed a survival rate of 80.92±5.77% for 1 mg/mL concentration range for cell viability evaluation-0.125-1 mg/mL. The inhibitory effect of nitric oxide (NO) production through RAW 264.7 cells induced by inflammatory response with lipopolysaccharide (LPS) resulted in an extract concentration of 25.58±3.11 μM (0.25 mg/mL), 13.91±3.86 μM (0.5 mg/mL), and 3.91±1.55 μM (1 mg/mL). The increase in concentration confirms an antiinflammatory effect. Conclusion: Ethanol extract of ginseng berry has excellent antioxidant and anti-inflammatory effects and can be a functional cosmetic material.

Recently, the development of eco-friendly and natural cosmetics materials has been steadily growing in the cosmetics industry to improve skin worldwide. With the development of biotechnology, the demand for functional cosmetics containing natural ingredients is increasing. Consumers seek natural ingredient cosmetics to maintain human body protection and homeostasis from harmful environmental factors. (Ham et al., 2018).Their so-called good values and consumption are seen as pursuing eco-friendly materials, and cosmetics materials of natural ingredients are especially recognized for their value. As a result, the fruits of plants and their extracts are steadily used as natural materials for cosmetics produced in Korea, and research on them is also continuously conducted. According to the results of the previous study, six berries types, including chokeberry, blueberry, raspberry, blackberry, mulberry, and cherry, were evaluated that the antioxidant and anti-inflammatory effects