An engineering product design considers derivatives to reduce the life cycle cost and to increase the efficiency on operation when it has new demands. The proposed design process in this study obtains derivative designs based on sensitivity of design variable. The efficiency and accuracy of the derivative design process can be enhanced by implementing global sensitivity analysis. Sensitivity analysis sensors the design variables accordingly and variables with low sensitivity for objective function can be neglected, since computational effort and time is not necessary for a design with less priority. In this research, e-FAST method code for global sensitivity analysis module was developed and implemented on Multidisciplinary Design Optimization (MDO) problem. The wing design was considered for MDO problem that used aerodynamics and structural disciplines. The global sensitivity analysis method was applied to reduce the number of design variables and Collaborative Optimization (CO) was used as MDO method. This research shows the efficiency of reduction of dimensionality of complex MDO problem by using global sensitivity analysis. In addition, this result shows important design variables for design requirement to student when they solving design problem.