Purpose:The aim of this study is to identify the factors influencing the existential spiritual well-being in the patients with alcohol dependence. Methods: The research design was a descriptive survey research with self-report questionnaire about existential spiritual well-being, self-esteem, trait anger, depression, family function, and interpersonal relations scale. Participants in the study were 240 patients with dependence who were collected randomly from 10 mental hospitals and 5 alcoholic centers and 1 alcoholics anonymous in Busan, Deagu city and Gyeongsangbuk-do and Gyeongsangnam-do region. Results: The forecasting regression model of existential spiritual well-bing appeared to be significant, the order of influencing factor was self-esteem (β=.36, p<.001), depression (β=-.38, p<.001), interpersonal relations (β=.18, p=.001), and not being employed for last one year (β=-.11, p=.007). Conclusion: The development of program which vitalizes the vocational rehabilitation and intervention is needed to increase the existential spiritual well-being of the patients with alcohol dependence by increasing the self-esteem and interpersonal relations and decreasing depression which are the major influencing factors.

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