In conditions of prolonged professional contact with penicillin and streptomycin, diseases may develop, the clinic of which is characterized by pronounced polymorphism and polysyndromicity, including lesions of the skin, internal organs and nervous system [1-7]. The main pathogenetic link in the development of this pathology is allergy [5, 7]. It is known that in allergic diseases, the functional state of the adrenal glands has a significant impact on the course and nature of clinical manifestations. However, the role of the functional state of these glands in the genesis of diseases caused by antibiotics has not yet been clarified.