The study enrolled patients with acute gastrointestinal ulcers and gastrointestinal bleeding, EGD confirmed, against the background of the novel coronavirus infection (61 patients). There were 39 men (63.9 %), women — 22 (36.1 %), the mean age of the patients was 57 years. It was found that preventive schemes of acid blockers administration have not been sufficiently effective and is unsafe for the patients with COVID-19. Based on this, as a prevention of the acute gastrointestinal ulcers in patients with the novel coronavirus infection without GI bleeding, we recommend the administration of the H2 receptor antagonists. The risk of gastrointestinal bleeding increases in patients with COVID-19, so there is a need for further investigation of the efficacy and safety of the preventive therapy in this category of patients.