We here report 2 patients who have acquired two consecutive episodes each of acute hepatitis, within 6 months after blood transfusion. The clinical and biochemical course was typical of recurrent acute viral hepatitis, and the patients recovered completely after each episode. The first infection was probably caused by non-A, non-B hepatitis virus, whereas the second episode was caused by hepatitis B-virus. Thus, in addition to the absence of cross-immunity between hepatotrophic viruses, one may simultaneously acquire more than one virus without apparent interference.