In the livers of the scorbutic guinea pigs the activity of p-hydroxyphenylpyruvic acid oxidase was found to remain unchanged but profoundly reduced after the feeding of extra tyrosine. Glucose cycloacetoacetate hydrolysate, a reducing compound, when ingested simultaneously with tyrosine was found to prevent the reduction in the enzyme activity. This effect was comparable to that of ascorbic acid.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.