Antigen S-100B of nervous tissue, according to the data of numerous studies, affects the mechanisms of nervous system plasticity and memory. The influence of ultralow doses of antibodies to S-100B (6C dilution, according to the homeopathic pharmacopoeia) has been studied on three learning behavioral models on Wistar rats, which were inhibitory avoidance, choosing of bowls with sucrose and feeding behavior cessation after auditory signal. For all three tasks, parameters of reproduction of the learned skills improved after per oral administration of potentiated antibodies to S-100B antigen immediately after learning. Possible mechanisms of the anti-S-100B antibodies influence on memory formation are discussed.

We studied the effect of potentiated antibodies against S-100B antigen on 20% sucrose consumption by Wistar rats under conditions of free-choice drinking from the bowls with sucrose and water during presentation of an acoustic pre-nociceptive or neutral signal. Peroral administration of antibodies after training sessions increased the number and duration of contacts with sucrose solution.

The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substances significantly reduced oxygen consumption intensified after morphinization. Potentiated morphine decreased the intensity of oxygen consumption to the level observed in intact animals. Our results indicate that morphine in ultralow doses modulates the action of this compound in toxic concentrations (bipathic phenomenon) and produces the normalizing effect. Potentiated antibodies to mu-opiate receptors modulated the effect of morphine, which indicates that they are involved in the development of opium dependence.

In experiments on rats we studied the effect of potentiated antibodies against S-100 antigen on training a step-down passive avoidance task and choice between drinking bowls with sucrose solution. Peroral treatment with antibodies accelerated inhibition of ineffective and punished locomotor reactions in animals.