Objective — improvement of methods of treatment of chronic generalized periodontitis based on the analysis of the cytokine profile of patients. Methodology. A study of 120 patients with chronic periodontitis of varying severity aged 30 to 50 years was conducted. All patients were randomized into 5 groups according to the severity of the disease and therapy. all patients received traditional anti-inflammatory therapy. In group 4, in addition to the main treatment, patients received laser therapy sessions. In group 5, patients with severe chronic periodontitis were administered remaxol along with laser therapy. Evaluation of the condition of periodontal tissues was carried out according to clinical indices. PMA, SBI, API, OHI-s, and periodontal indices were used. The serum levels of IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, and TNF-α were studied by enzyme immunoassay. Results: In chronic generalized periodontitis of moderate and severe severity, the content of all studied proinflammatory cytokines in the blood serum increases, and more significantly in the group of patients with severe disease. At the same time, the content of anti-inflammatory mediators undergoes ambiguous changes: in group I, the content of IL-4 increases significantly, and in group II it does not change significantly. In turn, IL-10 in group I does not decrease significantly, but in group II it becomes significantly less than normal. The inclusion of laser therapy and remaxol in the complex of standard measures showed high efficiency in reducing the severity of the pathological process, which was expressed in a faster subsiding of inflammatory phenomena in periodontal tissues. Conclusions: An increase in the content of proinflammatory cytokines in the blood serum in chronic generalized periodontitis was revealed, and more significantly in the group of patients with a severe course of the disease. At the same time, an imbalance of the system of pro-inflammatory and anti-inflammatory cytokines is registered. The use of laser therapy and remaxol in the complex treatment of CPT was the most effective.

Subject. In the modern world, the prevalence of cancer is growing every year, in this regard, this pathology is one of the most pressing problems in medicine. There is no doubt that malignant neoplasms have a complex interaction with the body. The General mechanisms of occurrence and progression of the tumor process are intensively studied, and to date, a huge amount of material on molecular and clinical Oncology has been accumulated, it is used in related disciplines. The most important sections of dentistry are the diagnosis and treatment of diseases of the mucous membrane. Often, clinical manifestations in the oral cavity are one of the first symptoms indicating a General somatic disease. This article covers the study of the dental status of patients with different localizations of cancer. Objective ― to study the incidence of dental diseases of patients with cancer. Methodology. To conduct a study medical examination of patients with different localizations of cancer was held to determine dental: the definition of DMF-Index, PMA-index, Parodontal Index, and the condition of the mucous membrane of the oral cavity and periodontal tissues. Cancer patients receiving chemotherapy and radiation therapy, patients who refused to participate in the survey were excluded from the survey. Results. The study included 526 patients. The predominance of certain types of dental diseases among patients with a particular cancer pathology was revealed. Conclusions. Our study showed that all patients had decompensated forms of caries. The most common dental diseases combined with cancer are hyperplasia filiform papillae (K14.3), the "geographic" language (K14.1). Periodontal disease occurred in 69,5 % of cases among cancer patients.

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