Abstract-The aim of this work is to evaluate the hepatoprotective effect of garlic homogenate co-administered with anti-tuberculosis drugs on the liver. Twenty rats were divided into five groups (each of four rats) designated A, B, C, D and E (control). 51.4mg/kg body weight of first line tuberculosis drugs (Isoniazid, Rifampicin, Pyrazinamide and ethambutol) was administered orally to two (2) rats in group A, B, C, and D for seven (7) days and the remaining two rats in each group for twenty-eight (28)