Резюме. Актуальність. Атеротромботичний підтип ішемічного інсульту становить 50 % випадків захворювання та є причиною інвалідизації працездатного населення середнього віку. Судинні порушення можуть бути пов'язані зі змінами у структурі генів ангіотензинперетворюючого ферменту (АСЕ), ангіотензиногену (AGT) та бета-фібриногену (FGB (OR = 0,303, 95% CI 0,688; р < 0,05, та OR = 0,303, 95% CI 0,688; р < 0,05 відповідно). Носії поліморфного генотипу -148СТ гена FGB частіше ніж удвічі ризикують захворі ти на ішемічний інсульт (OR = 2,452; 95% CI 1,005; р < 0,05) (2014-2016 рр.).
The article presents the analysis of the native and foreign literature data and also the results of our own research devoted to studying the role of herpes virus infection in the appearance and course of glomerulonephritis in children. There has been described pathogenesis and clinical aspects of virus associated glomerulonephritis in children. Much attention has been paid to the diagnostic methods of herpes virus infection in glomerulonephritis. The importance of association of immunosuppressive and antiviral therapy has been underlined.
It was found that addition of an extract from embryonic neural tissue (ENT), which contained 150 ~ug/ml proteins, to the culture medium favored viability of catecholaminergic neurons in cultured explants of the midbrain and medulla of newborn rats and establishment of contacts among these neurons. Addition of the ENT extract increased the dopamine level, measured at the 3rd-4th days of culturing, in the explants of the midbrain and medulla by 1.5 and 3.8 times, respectively. Similar indices for noradrenaline in the above structures were 2.5-2.6 times. The content of cAMP and cGMP in the explants increased 2.3 and 2.8 times, respectively, already 2-3 h after the ENT extract addition.
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