This research intends to examine the role of competence and work stress in terms of simultaneously and partially or separately on the performance of nurses at RSJ Provinsi Bali. The research design used is causal quantitative research. The sample determined in this study used the proportionate sampling method. The number of samples used was 104 respondents. The instruments used when collecting data are by means of observation, recording documents, and distributing questionnaires, and the data analysis technique used is multiple linear regression analysis. The results showed: (1) Competence and work stress have an important influence on the performance of nurses at RSJ Provinsi Bali. (2) Competence has an important and positive role for the performance of nurses at RSJ Provinsi Bali (3) Job stress has an important and negative role for the performance of nurses at RSJ Provinsi Bali.