The trial was conducted to investigate effect of hydrolyzed render meal and skin derived protein meal on the egg production performance, eggshell quality, egg quality and blood characteristics in laying hens. A total of 280 44 week (wk) old (Hy-Line brown) laying hens were used in this 6-wk trial. Birds were randomly assigned to 1 of 4 treatments, 1) BD, basal diet; 2) HRM, basal diet with 2% hydrolyzed render meal; 3) SSM, basal diet with 2% swine skin meal; 4) CHM, basal diet with 2% cattle hide meal with 14 replications per treatment and 5 adjacent cages as replications. During wk-44 to 46, the egg production (%) was significantly higher (P < 0.05) in SSM treatment (96.37 and 97.10) than others. Overall, egg production was higher (P < 0.05) in SSM treatment (96.79%) than CHM, HRM and BD treatments (96.16%, 95.90% and 95.30%) respectively. In case of average daily feed intake (ADFI), SSM showed significant higher (P < 0.05) value (120g) than BD treatment (117 g). Both SSM and CHM treatments seemed higher (1.009) egg gravity than BD treatment (p < 0.05) at 50-wk. On the other hand, at the same time, egg weight was significantly higher (P < 0.05) in BD treatment compared to others. The egg quality and blood characteristics were unaffected (p > 0.05) by dietary treatments. In a nut shell, the skin derived protein meal supplemented in laying hen diet at 2% enhanced the egg production performance of laying hens and inoffensive to the egg quality and laying hen health status.