Die Synthese von neuartigen Polymethinfarbstoffen wie (III), (VI), (VIII) oder (XI) mit 2,2‐Difluor‐1,3,2‐dioxaborinresten wird beschrieben (Weitere Beispiele im Original).

A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on β-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the reaction mechanisms and metabolic processes using radioactive indicators.Keywords: N-phenylquinolinium and quinaldinium salts, tritium, phenyl cations, six-membered nitrogen heterocyclic compounds, chemonuclear synthesis.Fragments of quinoline and isoquinoline are part of many alkaloids and enzymes. Together with natural therapeutic preparations, such as quinine and papaverine, a large number of effective synthetic drugs has been developed: chloroxine, cyprofloxacin, norfloxacin, etc. [1-3]. A large contribution to the development of methods of synthesis and study of the biological activity of quinoline derivatives has been made by Soviet scientists [4,5]. It was established on biological monitoring that lipophilic derivatives of quaternary nitrogen, and particularly quinolinium salts, display higher biological activity. In many cases N-phenyl compounds surpass their aliphatic analogs. In spite of the large number of studies and the broad aspects of biological and medicinal application (antiseptics, biocides, antimalarials, antitumor, antirecidive, and antipyretic preparations) [6][7][8][9][10][11][12][13][14], the search still goes on for new biologically active compounds in the area of quinoline derivatives [15][16][17][18][19][20][21][22][23][24][25][26].

Die durch Einführung fünf‐ oder sechsgliedriger Ringe in die Polymethinkette bewirkte bathochrome Verschiebung der Absorptionsmaxima beträgt für die Thiatricarbocyanine (IVa) und (VII) etwa 45 bzw. 5 nm, für die Chinotricarbocyanine (Va) etwa 68 bzw. 20 nm.

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