The results of a laboratory examination of 520 children aged 1—3 years are presented. The examination was conducted to determine the DNA of cytomegalovirus in children with acute cytomegalovirus infection in various biological media by polymerase chain reaction. The differences in the virus shedding into the blood, saliva, and urine are established: the median of the viral load for saliva is 4.9 lg copies of DNA/ml, the blood 3.4 lg copies of DNA/ml, urine — 3.85 lg copies of DNA/ml. The cut of extreme values of the viral load are determined with the help of mathematical modeling which determine the clinical probability of developing acute CMV infection which allows for more accurate and timely assignment of etiotropic therapy.
Представлены результаты комплексного клинико-лабораторного обследования 146 детей в возрасте 2-3 лет, посещающих ДДОУ. Установлены и научно обоснованы ведущие предикторы частой респираторной заболеваемости: нарушение микробиоценоза слизистой ротоглотки, гипоиммуноглобулинемия, респираторная аллергическая патология. Полученные результаты позволяют обосновать основные направления лечебно-профилактических мероприятий. Ключевые слова: часто и длительно болеющие дети, острые респираторные инфекции, предикторы, математическая модель
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