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Synthesis of Seco-Acids of the Dammarane Series.-The synthesis of the title acids (IV) and (V) is presented. Whilst acid (V) (yield in g) is obtained directly by chromic acid oxidation of alnincanone (I), the acid (IV) is formed via the hydroximino derivative (II) and nitrile (III). Both acids show activity against influenza type A virus. -(ZORINA, A. D.; MIKHAILOV, YU. D.; BALYKINA, L. V.; SMIRNOV, I. I.; PLATONOV, V. G.; GORDON, M. A.; CHIZHOV, N. P.; SHAVVA, A. G.; Khim. -Farm. Zh. 31 (1997) 6, 52-54; Nauchno-issled. inst. khim. St. Peterburgskogo gos. univ., St. Petersburg, Russia; RU)

The review presents the results of clinical studies of the efficacy and safety of Tenoten and Tenoten children’s in the treatment of anxiety, neurotic, stress-related and somatoform disorders and adjustment disorders. Technologically processed antibodies to the S100 protein in Tenoten and Tenoten children’s drugs change the conformation of the S100 protein, which is considered as a pathological link in the development of anxiety states, as well as neurodegenerative diseases. Tenoten is a well-studied daytime anxiolytic that combines a favorable safety profile with high anxiolytic activity. The efficacy of Tenoten in the treatment of anxiety disorders is comparable to that of benzodiazepine drugs. Tenoten has no inhibitory and muscle relaxant effects, does not cause drug tolerance, addiction, "withdrawal" syndrome, as well as drug interactions. Tenoten for children has been shown to be effective in the treatment of anxiety in children, including those with somatic manifestations, attention deficit hyperactivity disorder, and learning disabilities.