Introduction: Antidiabetic oral was not optimal for reducing blood glucose, patients use the various antidiabetic herbs along with antidiabetic drug for controlling their blood glucose level. Aloe vera is one of the plants that are often used by diabetic patients who are also taking antidiabetic medication and susceptible arise interaction between them. Objectives of this study is to determine the effect of Aloe vera juice and glibenclamide combination in reducing blood glucose levels in the diabetic rats model induced by streptozotosin and nicotinamide. Method: Research metodology the diabetic rats were randomized Latar Belakang: Penderita DM diperkirakan meningkat setiap tahunnya dan terkadang penggunaan obat antidiabetik tidak optimal dalam menurunkan glukosa darah. Kondisi ini membuat kebanyakan pasien berinisiatif untuk memanfaatkan tanaman obat yang dianggap berkhasiat untuk menurunkan kadar glukosa darah. Salah satu obat herbal yang sering digunakan adalah Aloe vera. Padahal penggunaan kombinasi obat antidiabetik dengan Aloe vera dapat menimbulkan interaksi. Tujuan Penelitian untuk mengetahui pengaruh kombinasi jus Aloe vera dan glibenklamid dalam menrunkan kadar glukosa darah pada model tikus diabetes yang diinduksi dengan streptozotosin dan nicotinamide. into three groups and administered CMC 0,5%, glibenclamide, or Aloe vera and glibenclamide. The animals were treated orally once daily for twentyeight days. Data were analyzed using one way Anova Result: Findings of this study indicate that of Aloe vera juice in combination with glibenclamide significantly reduced blood glucose levels significantly in diabetes rats model (p<0,05) Conclusion: Combination of Aloe vera juice and glibenclamide be able to lower blood glucose levels and statistically significant. Metode: Metode Penelitian menggunakan tikus yang diinduksi menjadi diabetes melitus dibagi menjadi 3 kelompok yang menerima perlakuan berupa plasebo CMC 0,5 %, Glibenklamid dan kombinasi jus Aloe vera dan glibenklamid. Perlakuan diberikan setiap hari selama 28 hari. Data dianalisis menggunakan uji One way Anova Hasil: Hasilnya adalah Kombinasi jus Aloe vera dan glibenklamid signifikan secara statistik menurunkan kadar glukosa darah pada model tikus diabetes (p<0,05). Simpulan: Kombinasi jus Aloe vera dan glibenklamid mampu menurunkan glukosa darah dan signifikan secara statistik.

Background :The hemodynamic relationship between the heart and the kidneys is closely related. Cardiorenal syndrome in general can be defined as a condition of pathophysiological disorders of the heart and kidneys, in which acute or chronic dysfunction of one organ results in acute or chronic dysfunction of other organs.. The cardiorenal syndrome proceeds like an interconnected loop where heart failure can exacerbate chronic kidney failure and vice versa. Method :Research design analytic observational with cross sectional approach with the population is Chronic Kidney Failure (CKD) patients undergoing Hemodialysis (HD) program at North Lombok Hospital. Aim :The purpose of this study was to see if there was a relationship between the duration of hemodialysis in CKD patients and the incidence of congestive heart failure (CHD).Results : Statistical test results using Spearmen Test shows that from a total sample of 51 people, the correlation coefficient rof 0.446 and the value of Sig (p) = 0.001 (p <0.05). Based on these results, it can be concluded statistically that there is a significant relationship between the length of HD and the degree of HF based on the New York Heart Association (NYHA). Conclusion :There is a statistically significant relationship between the duration of HD and the degree of CHD based on the NYHA. The relationship is positive, which means that the longer the duration of HD, the higher the degree of NYHA in patients with CHD.