Background: Best clinical judgment is currently used to estimate the likelihood that a patient referred for a liver transplant (LT) will survive after the operation. The primary aim of this study was to assess if perioperative risks (< 24 hours) could be stratified using the liver transplant risk score (LTRS), a prognsotic model previously developed to estimate the risk of postoperative mortality based on recipients' preoperative characteristics. Secondary aims were to assess if the model could also stratify the risk of 30day, 1-year mortality and patient survival beyond the first year. Methods: The LTRS was calculated using parameters available when patients were listed for LT: MELD score, BMI, Age, Diabetes, and Renal Failure (defined as the need for dialysis). Mortality rates at 24 hours, 30 days, and 1year were compared among group of patients with different LTRS. Patients with ABO-incompatible LT, redo, multivisceral, partial graft and malignancies except for hepatocellular carcinoma were excluded. The demographic and preoperative clinical characteristics of 18,635 adults who had a LT in the United States between 2013 and 2017 were extracted from the Scientific Registry of Transplant Recipients.