A 16-year-old white Brazilian man presented with a main complaint of painful oral lesions of 5 months' duration. He also reported weight loss of 3 kg in the past 3 months and a 1-year history of occasional bilateral hip arthralgia Otherwise he was generally well, and personal and familiar antecedents were unremarkable.Physical examination of the oral cavity revealed two vegetating ulcers orientated along both mandibular vestibular sulci, with symmetrical distribution (Fig. 1a,b). Routine blood investigation detected microcytic anaemia, reduced serum albumin level and elevated C-reactive protein and erythrocyte sedimentation rate.
Histopathological findingsA punch biopsy was obtained from the edge of one of the ulcers. Histopathological findings are shown in Fig. 2(a,b). Briefly, a dense inflammatory infiltrate along the lamina propria, comprised of multiple noncaseating granulomas was observed. The noncaseating granulomas were composed of epitheloid cells and multinucleated giant cells. Specific stains for fungus and mycobacteria were negative.What is your diagnosis? C P D Figure 1 Linear ulcers on the mandibular vestibular sulcus, (a) right, and (b) left.Figure 2 (a) Presence of a dense inflammatory infiltrate along the lamina propria, constituted by multiple noncaseating granulomas; (b) detailed noncaseating granulomas composed of epitheloid cells and multinucleated giant cells. Haematoxylin and eosin, original magnification (a) · 40; (b) ·100. Special stains for fungus and mycobacterias were negative.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.