In the present work new criteria of optimal design method for turbine runner [1] are proposed. Firstly, based on the efficient method which couples direct simulation of 3D turbulent flow and engineering semi empirical formulas, the combined method is built for hydraulic energy losses estimation in the whole turbine water passage and the efficiency criterion is formulated. Secondly, the criterion of dynamic loads minimization is developed for those caused by vortex rope precession downstream of the runner. This criterion is based on the finding that the monotonic increase of meridional velocity component in the direction to runner hub, downstream of its blades, provides for decreasing the intensity of vortex rope and thereafter, minimization of pressure pulsation amplitude. The developed algorithm was applied to optimal design of 640 MW Francis turbine runner. It can ensure high efficiency at best efficiency operating point as well as diminished pressure pulsations at full load regime.