The use of glyphosate (720-2880 g/h a.i.) and ammonium glufosinate herbicides (375-1500 g/h a.i.) to control of common ragweed (Ambrosia artemisiifolia L.) has been studied in trials (2013-2018) in the vineyards of Rkatsiteli, Liang and Cabernet Sauvignon in Abinsk district of Krasnodar region. Accounting of weeds was done by a quantitative method with counting the number of each weed species in each plot. Counts were performed before the treatment and in 15, 30 and 45 days after spraying. The effi cacy of herbicide was determined in relation to the untreated control and expressed as a percentage. The main evaluation criterion was the eff ectiveness of 100 % in one of the accounts or the average (for all counts) effi ciency of more than 90 %. The results showed that in 95 % of trials spraying of 1440 g/h of glyphosate 1440 g/h of glyphosate (a.i.) and higher ensured processing effi ciency exceeding 90 %. Herbicides such as Roundup, containing 360 g/l of isopropylamine salt, can be recommended for use to control of common ragweed in the application rate 4.0 l/ha. Destruction of all common ragweed observed when using not less than 600 g/h glufosinate ammonium. Thus, Herbicides such as Basta, containing 150 g/l of ammonium glufosinate, to control of common ragweed should be applied by fractional application vegetative weeds (2.5 l/h + 1.5 l/h).