The present clinical study was carried out to validate the efficacy and safety of Siddha Herbo- mineral formulation ‘Kodipavala Chunnam’ in the treatment of Infective hepatitis, Drug induced hepatitis and Alcoholic hepatitis. Open clinical trial was conducted in 40 patients with these three categories of hepatitis in Arignar Anna Govt.Hospital of Indian Medicine and Homeopathy, Chennai. The trial drug Kodipavala Chunnam was administered in all the patients at the dose of 100 mg to 200 mg thrice a day with honey depending on severity. The clinical improvement shown by cases treated with Kodipavala Chunnam was more quick and significant. Before drug administration to patients it was observed that a significant increase in the levels of serum bilirubin ALT, AST, SAP, GGT and globulin. Elevated levels of these parameters are indicative of functional impairment of liver. Administration of KPC remarkably (P<0.001) restored elevated serum bilirubin ALT, AST, SAP, GGT and globulin towards normal value. Overall results revealed that out of 40 patients 10 patients had excellent relief, 26 had good relief, 3 cases showed satisfactory result and only one case showed fair response. The results clearly have shown that the Kodipavala Chunnam treatment to the jaundice therapy helped in cutting down the course of the disease and relieving jaundice earlier. There were no new or unexpected safety events noticed during the course of the treatment

Milagaranai Ver Chooranam (root of Toddalia asiatica) is one of the Siddha herbal drugs; which has been indicated for its anti-microbial properties. The aim of the present study was to validate anti-bacterial and anti-fungal activity of Milagaranai Ver Chooranam (MVC) extract against various microorganisms. The microorganisms used in the present study include Escherichia coli, Salmonella typhi, Shigella flexneri, Xanthomonas maltophilia, Proteus vulgaris, Chromobacterium violaceum, Streptococcus pyogens, Staphylococcus aureus, Staphylococcus albus and Candida albicans. The anti-microbial study was conducted according to the agar diffusion method. Ciprofloxacin (10 μg) and Ketoconazole (10 μg) were employed as standard drugs for anti-bacterial and anti-fungal studies respectively. It was observed that MVC extract exerted effective anti-bacterial activity against almost all the organisms tested, when compared to the standard drugs which was evident from the zone of inhibition. The drug Milagaranai Ver Chooranam showed the minimum inhibition of the growth of microorganism at 100 μg/ml concentration for all the organisms. This bioactivity is mainly due to the presence of alkaloids, flavonoids, glycosides, tannins, saponins and coumarins known for its effectiveness against microbial agents. Our results confirmed the traditional use of Milagaranai Ver Chooranam as an anti-microbial agent.

Iron deficiency is the most common and widespread nutritional disorder in the world. India is among the countries with highest prevalence of anaemia in the world. It has serious consequences for the health and well-being as well as social and economic impacts of India. Untreated iron deficiency anaemia can become severe enough to interfere with daily life. Knowledge of iron deficiency and its treatment in Siddha System of medicine dates back from time immortal. Many plants in Siddha system of medicine are known to have remarkable effects in treating anaemia. One such medicine is "Echuramooli Leaf Chooranam" Aristolochia indica Linn. The haematinic activity of Echuramooli Leaf Chooranam was studied in Phenylhydrazine induced anaemic rats. Anaemia was induced by an oral administration of Phenylhydrazine for a period of 7 days. The Echuramooli Leaf Chooranam was administered at the various dose levels of 50 mg/kg, 100 mg/kg and 200 mg/kg orally to the animals for 14 days. Hb concentration, RBC count, PCV, MCH, MCHC were analysed as indices of anaemia. Phenylhydrazine significantly decrease the haematological parameters. After 14 days of treatment with trial drug Echuramooli Leaf Chooranam at the dose level of 200 mg significantly reverse the above parameters and turn towards the normal value. This result supports the traditional use of Echuramooli Leaf Chooranam in the treatment of anaemia.