No abstract

The pharmacokinetics of eltoprazine in healthy male subjects was investigated after intravenous and oral dosing in one study, and after oral dosing of 14 C-eltoprazine in a second study. It was shown that the absorption of eltoprazine from the gastro-intestinal tract was complete, and that absolute bioavailability was 100%. The mean elimination half-life of eltoprazine in plasma was about 8 hours. Approximately 40% of the dose was excreted unchanged in urine. J. van Harten, I.S. Mathlener and Μ. Raghoebar Drug Metabolism and Drug Interactions 157Brought to you by | provisional account Unauthenticated Download Date | 7/13/15 6:53 AM