BACKGROUND:Bone marrow examination is a commonly used diagnostic modality in the evaluation of hemato-oncological disorders and in patients with malignancies of visceral organs to detect metastasis. This study reviews clinical, hematological and pathological data of interesting cases with bone marrow involvement. Out of 490 bone marrow aspirations performed during a period of 4 years, 5 cases show metastatic carcinomatous deposits which included adenocarcinomas(3), squamous cell carcinoma(1) and neuroendocrine tumour(1), Non-Hodgkins lymphomas(2), storage disorder(2), granulomatous lesions(1), gelatinous transformation(1). Fever, generalized weakness, loss of appetite and loss of weight were the main symptoms. Anemia and pancytopenia were the main hematological findings. Dry tap was a significant finding in bone marrow aspiration in cases of metastatic cancers.

Cutaneous metastasis of rectal carcinoma is rare, it occurs in <4% of patients with rectal cancer. When present, it typically signifies a disseminated disease with a poor prognosis. Early detection and proper diagnosis of metastatic colorectal cancer can significantly alter treatment and prognosis. We report a case of 65 yr old man who presented with skin nodules on the neck, axilla and abdominal wall. Fine needle aspiration cytology of skin nodules was suggestive of signet ring cell carcinoma. Skin lesion biopsy also showed signet ring carcinoma. Patient had a history colorectal carcinoma two months before he developed skin nodules. Final diagnosis of cutaneous metastasis of signet ring cell rectal carcinoma was made based on Fine needle aspiration cytology(FNAC), Histology and Immunohistochemistry.

Infantile hemangioendothelioma is a benign neoplasm of the salivary gland .The lesion is comprised of round to oval cells with few spindle cells arranged in vascular channels .We present a case of 15 month old female child with swelling in the submandibular region. Radiologically the lesion was found to be of submandibular gland origin .Fine needle aspiration yielded only blood elements .Excision was done and histology showed morphology of Infantile hemangioendothelioma. Infantile hemangioendothelioma of salivary glands was reported in parotid gland, but its occurrence in the submandibular gland has not been reported till now to the best of our knowledge.

: Idiopathic thrombocytopenic purpura(ITP) presents as a primary form characterized by isolated thrombocytopenia (platelet count < 100 × 109/L)