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Natural ecdysteroids isolated from Serratula coronata L., including 20-hydroxyecdysone (20-HE), 25-S-inokosterone, and ecdysone, did not exhibit antimicrobial activity with respect to most standard test microbe cultures. The introduction of the acetyl group into the 20-HE molecule significantly increased the antibacterial activity with respect to microbes inducing inflammatory and purulent processes. Acyl derivatives of 20-hydroxyecdysone can be suggested for use in wound-healing compositions 268 0091-150X/06/4005-0268

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Administration of steroid glycosides of both the spirostanol type, where the active substance is deltonin, and the furostanol type, the main components of which are deltoside and protodioscine, before transplantation of Ehrlich carcinoma (EC) and during its growth had no effect on the body's resistance to tumor cells, with no effect on the latent period of formation of tumor nodules or the rate of tumor growth. Testing in a therapeutic regimen demonstrated a tendency to stimulation of EC growth in response to spirostanol glycosides. At the same time, treatment with furostanol glycosides showed weak, statistically insignificant, inhibition of tumor growth, in terms of both tumor volume and tumor mass.

No abstract