To increase the productivity of animals and reduce the cost of production, it is necessary to provide animals with a sufficient and high-quality level of feeding, to keep animals in appropriate conditions, to carry out high-quality and timely disinfection, which will lead to a decrease in pathogenic micro flora in the premises where animals are kept, there will be a break in the epizootic chain of disease spread. In modern animal husbandry, which is characterized by a significant accumulation of animals on a limited area, increased requirements for the quality and ecological products, and the prevention of infectious, invasive and especially anthropozoonous diseases, the leading place is occupied by disinfection. It is one of the most important directions in the complex of measures to combat infectious diseases, which prevents significant economic losses as a result of infection. Disinfection is also the cheapest, most availiable and highly effective method of disease prevention. The disinfectant market of Ukraine has a wide range of simple and complex preparations that can be used for disinfection. However, most of them do not meet modern requirements regarding solubility, activity against a wide range of microorganisms, the influence on biofilms of microorganisms, formation of resistance, anti-corrosion activity, the influence on the organism, environmental safety, universality. Among the new biocidal preparations used in human and veterinary medicine and which most fully meet the modern requirements for disinfecting properties, the leading place is occupied by polymeric compounds of guanidine, in particular polyhexamethyleneguanidine (PHMG). This preparation is an effective solution to the problem of combating infectious diseases that cause significant economic losses not only in animal husbandry, but also at the medical and ecological level. PHMG does not have a cumulative, sensitizing, irritating or skin-resorptive action. Disinfectants with polyhexamethyleneguanidine have a prolonged action and show the activity under conditions of changing pH, have long-term storage and are stable during transportation, can be used in various ways (spraying, watering, wiping, dipping, soaking, pouring, etc.), after use they form films with a long-lasting bactericidal effect, they can be disinfected in the presence of animals and people.