In the first hour simulated fecal peritonitis development in the rats blood revealed an increase in the level of diene conjugates and malondialdehyde (p <0.001 compared with the results of intact animals. In second stage was detected more pronounced increase in the level of primary and secondary products of lipid peroxidation (p <0.001) as compared with the data of the same hole in the first stage, and compared with the results of group No. 1). On the 3rd day of simulated peritonitis development in rats there is a marked deterioration of the animal condition, which was manifested in lipid peroxidation progression: the diene conjugates level increased at the level of significance p <0,001, and the level of malondialdehyde compared to p <0,05 data from the previous stage of the same group.

In the report of the World Health Organization from 1990 to 2016 to this day, Ukraine continues to occupy first place in the European region in morbidity and mortality from diseases of the cardiovascular system. One of the predictors and key links in the development of CVD is endothelial dysfunction. In this work, it was shown that chronic loading with sodium nitrite provokes the development of oxidative stress (an increase in 2,3bisphosphoglyceric acid), inflammation (an increase in the level of interleukin-1-beta, which, in turn, causes a sharp increase in iNOS activity), the development of endothelial dysfunction (increase in von Willebrand factor). L-arginine alone, and in conjunction with the drug "Vin-Vita" cause a decrease in the negative effect of sodium nitrite.

The article presents the results of an experimental study of the AOР and LPО system in animals simulated complications of the microcirculatory tract (diabetic retinopathy, diabetic nephropathy) on the background of type 2 diabetes. It was found that in the group of animals with type 2 diabetes increased the level of DC, TBCproducts and MDA; catalase and FG levels decreased. In animals with simulated DN, AOP disorders were more pronounced compared to animals with DR. This trend can be explained by the fact that in addition to hyperglycemia in these animals, the excessive formation of free radicals contributes to metabolic shifts in ischemic areas of tissues and organs. Disturbance of balance in AOP and LPO in type 2 diabetes triggers a pathogenetic cascade of development of complications of the microcirculatory tract and is accompanied by a tendency to further increase the generation of reactive oxygen species and activation of POL in microangiopathies.

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