The total synthesis of 3-chloro-4-(D-ribofuranosyl)-pyridine and 3-(D-ribofuranosyl)-2-pyridone was elaborated using the appropriate lithiopyridines and 2,4:3,5-di-O-benzylidene-aldehydo-D-nbose. The conformation of these compounds was investigated by 360 h4Hz IH-NMR. The compounds were evaluated as a$-mixtures for their antiviral and cytostatic properties. However, no significant biological activity was found.
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