Haematological malignancies are major cause of mortality and morbidity worldwide. The aim of this review was to summarize some of the challenges that hamper proper diagnosis and management of haematological malignancies in Nigeria and how they affect outcome. MEDLINE Entrez PubMed, Google scholar and African Journals Online (AJOL) search were performed in April 2020 and studies that investigated challenges in diagnosis and management of haematological malignancies from 2005 to 2019 were sought. Search keywords included “haematological malignancies, challenges, Nigeria”. Only studies that provided information on the challenges of diagnosis and management of haematological malignancies in Nigeria were eligible and were selected. Inclusion criteria were original scientific investigations or case reports, not reviews, studies conducted in Nigeria between 2005 and 2019 and studies written in the English language. A total of eight relevant studies that fulfilled the study inclusion criteria were identified out of 4,129 studies found. Challenges of diagnosis and management of haematological malignancies reported by the studies include late presentation of patients in advanced stage of disease, inability to pay for investigations and/or treatment due to financial constraint, wrong/ delayed diagnosis due to poor diagnostic facility such as use of only morphology for histological diagnosis without immunohistochemistry and poorly equipped health facilities to manage haematological malignancies. Poor outcome as a result of those challenges were also reported by the studies. Awareness creation and education on the importance of early presentation to health facility should be encouraged. Health system should be strengthened by including haematological malignancies in National Health Insurance and providing well equipped health facility for proper diagnosis and management of haematological malignancies.

Objective: Pyridoxine, is essential in the metabolism of many classes of food, we aimed at determining the effect of its supplementation on the quality of life (QoL) of patients with chronic lymphocytic leukaemia (CLL). Methods: This study compared the (QoL) and haematological parameters of CLL patients before and after the administration of pyridoxine. Data obtained were analyzed using SPSS version 19. Results: There was improvement in the QoL of the patients after pyridoxine supplementation; Majority of the parameters that make up the physical functional scales was significantly higher after pyridoxine supplementation. There were also significant improvements in insomnia, appetite loss and constipation after pyridoxine supplementation. Conclusion: Pyridoxine supplementation in patients with CLL marginally improved quality of life.