The sustainable preservation of monuments requires the use of performing materials which are at the same time compatible with the monument’s historical building materials to ensure structural integrity, adequate performance of the structure in earthquake stresses, and resilience of both restoration and historical materials. This is especially true for cultural heritage assets that have experienced major destruction, demanding extensive reconstruction. The Plaka Bridge in Epirus, Greece, partially collapsed after a heavy rainfall in 2015. It was a supreme example of traditional stone bridge architecture of the region and an important landmark. In the present study, a potential restoration stone from a nearby quarry was examined in terms of compatibility in relation to the dominant historical building stone of the bridge, as well as in terms of mechanical performance, through a variety of in lab techniques. In addition, criteria were set for restoration mortars, taking into account the characteristics of the historical materials, as well as the environment of the bridge. The results of the study regarding the restoration stone and mortars are presented and assessed, in order to select the most appropriate restoration materials for Plaka Bridge in its upcoming restoration, aiming to enhance the overall resilience of the structure.