Summary Anti-tumour responses with CCRG 81010, M & B 39565, NSC 353451, (Muggia, 1987). The limited clinical activity observed amongst anti-cancer drugs is likely to be a direct result of the methods used in their selection. The most striking finding is the extent to which the activity discovered amongst the drugs is confined to the haematological malignancies. While this may represent innate sensitivity of these tumours to cytotoxic agents it may also be that the pre-clinical screening programmes of the NCI, based heavily on the murine leukaemias, select new agents active primarily in human leukaemia and lymphoma (Marsoni et al., 1987). Furthermore a radical departure in the screening programme in the NCI is now underway but nevertheless carefully chosen transplantable mouse tumours can (and should) have their place in the new strategies being developed (Corbett et al., 1987).Mitozolomide [CCRG 81010, M&B 39565, NSC 353451, 8-carbamoyl-3-(2-chloroethyl) AnimalsPure strain NMRI mice aged 8-10 weeks from our inbred colony were used. They were fed on CRM diet (Labsure, UK) and water ad libitum. Tumour systemThe development of several adenocarcinomata of the large bowel in NMRI mice from primary tumours induced by prolonged administration of 1,2-dimethylhydrazine has been described elsewhere . BML1 is a spontaneous lymphoma, derived in this laboratory, which has been serially passaged by intraperitoneal (i.p.) inoculation of Br.

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This study was carried out by partial purification of prolidase from blood serum patients with preeclampsia by ion exchange The degree of purification enzyme (1. 85) fold, enzyme yield (8.82) and specific activity is (8.88) IU/mg .The kinetic studies of partially purified The enzyme technology demonstrated the optimal substrate concentration which was (97) mmol/L and Vmax (71.42 )(U/L),km(1.25) while optimal The optimum temperature was (37°C) and pH (9.2). molecular The weight of the partially purified enzyme was determined by a gel Electrophoresis method, in the presence of polyacrylamide gel and sodium Dodecyl Sulfate (SDS_PAGE) which showed that the approximate. The molecular weight was (54KD). We found a high level of Erythropoietin hormone in Pre-eclampsia patients which was a significant (P≤0.01) increase, (438.47  ) when she was in Control (251.70  ), the value of antidiuretic hormone in the patient was a significant (P≤0.05) increase (7.343)  while in Control decrease value (2.155), the value of the ALD hormone in the patient was a significant decrease (P≤0.05)  (288.7) and control was (143.6), Nitric Oxide in the patient was a significant (P≤0.05)   (30.0) and control was increase (44.2) and vitamin D in the patient was a significant decrease (P≤0.05) (11.04) and control was(15.78) We conclude from the above results that there are some variables that rise with preeclampsia, such as the hormone ADH and the hormone EPO, but other variables such as ALD, vitamin D3 and nitric oxide decrease with increased pregnancy pressure, that is, with preeclampsia, in addition to that the main objective of the research is to purify the prolidease enzyme in the serum of women with preeclampsia and to know the duration of its effect This enzyme on pregnant women and linked it in another study with materials to find a new treatment

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