A novel synthesis of derivatives of the title ring system by reacting methylpyrazolo[5,1-c]-1,2,4-triazin-6-carbonitriles (9) with sulphur and subsequent treatment of the resulting thienopyrazolotriazines with acetivated double bond system is described.

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A series of new thioxopyrimidine, 4H-pyrans, pyranopyridine and pyranopyrimidine derivatives with expected biological activity have been prepared through the reaction of 6phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one 4 and 7-Amino-5-(4-chlorophenyl)-4phenyl-2-thioxo-2,5-dihydro-1H-pyrano[2,3-d]pyrimidine-6-carbonitrile 11b with some electrophilic reagents and nucleophilic reagents. The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. RESULTS AND DISCUSSIONSPyrimidinethione 4 was prepared through the two-component reaction of thiourea and ethylbenzoylacetate. The structure of the reaction product could be SINAI Journal of Applied Sciences 52 Elian, et al.

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Many heterocyclic compounds were prepared from the reaction of 2-imino-6-phenyl-2,3dihydropyrimidin-4(5H)-one 4 with some bifunctional nucleophiles and electrophiles reagents under mild conditions .The structure of the synthesized compounds were established via their elemental and spectral analysis. Some of the products were also screened in vitro for their biological activity.