This study was conducted to assess the potentials of Azadirachta indica (L.) in the removal of heavy metal from soil contaminated with lead poisoning in Anka, Zamfara State. Soil and Azadirachta indica samples were collected and analyzed for physico-chemical and heavy metals. Contamination and transfer factors were also calculated. The results of physico-chemical parameters revealed that Anka (control) has highest pH H20 (1:2.50); 7.63, Organic Carbon (OC); 1.54%, Total Nitrogen (TN); 1.91%; Cationic Exchange Capacity (CEC); and 5.52cmol kg −1 . Abare has the highest values of Available Phosphorus (AP); 32.55 mg/kg, Electrical Conductivity (CEe); 1.33d/sm. The textural classes were Loamy Sand (LS). The highest concentrations of heavy metals were in Abare; Zn (54.68mg/kg), Mn (51.19mg/kg), Pb (493.85mg/kg) and Cd (3.78mg/kg). The highest CF of all the heavy metals was found in Abare with Zn (0.18), Mn (0.03), Pb (4.94) and Cd (1.26). Bagega has the highest concentrations of transfer factor (TF) of Mn (2.10), Pb (1.48) and Cd (0.75) while Anka town has the highest TF of Zn (2.53). The results obtained showed that soil physico-chemical properties enhance mobility and availability of heavy metals. Azadirachta indica can accumulate heavy metals from contaminated soils as the concentrations of the heavy metals were reduced in the polluted soils. The contamination factors revealed that most values fall within none to medium contamination due to the phytoremediation potential of the plant. Thus Azadirachta indica posses high phytoremediation potentials as it helps in reducing the high amount of heavy metals in the soil.