A two-year field study was carried out at the Agricultural Experiment Station, Alexandria University in 2017/2018 and 2018/2019 winter seasons to investigate the effect of foliar spraying of humic acid (HA) (0 and 2.4 kg/ha) and both Fe and Zn micronutrients (0, 480 and 960 g/ha of FeSO4 and/or ZnSO4, respectively) on three durum wheat cultivars (Casino, Bani Sweif6 and Sohag3). The experiment was laid out in split-plot design with three replications, where combinations of HA levels and cultivars occupied the main plots, while combinations of Fe and Zn levels were randomly allocated to the sub plots. Bani Sweif6 was superior to the other two cultivars for all studied grain yield and yield components except for 100-grain weight. Application of humic acid increased grain yield of Bani Sweif6 and Sohag3, but negatively affected that of Casino. Application of 480 g/ha of both FeSO4 and ZnSO4 gave the highest values with HA application in Bani Sweif6 and Sohag3, and without HA application for Casino. It is recommended to spray Bani Sweif6 and Sohag3 with 2.4 kg/ha HA and 480 g/ha of both Fe and Zn, while more studies are needed to determine the suitable level of HA spraying for Casino cultivar.