Scholars have widely discussed the paradigm of integration of Islam and science. Still, a model of integration of Islam and science that uses the reasoning of Martabat Tujuh [seven grades] has not been found. Therefore, this study sought to investigate the manuscripts of Shaykh Abdussamad al-Palimbani’s Martabat Tujuh in the integration of Islam and science. This study used a descriptive qualitative approach, and data collection techniques were documentation and interviews. This study found two spiritual reasons in the manuscript of Shaykh Abdussamad al-Palimbani’s Martabat Tujuh: tanazzul [move down] deductive reasoning and taraqqi [move up] inductive reasoning.Contribution: The article contributed to developing the integration of Islam and science in Indonesia. The manuscripts of Martabat Tujuh [seven grades] by Shaykh Abdussamad al-Palimbani offer the circular motion of Martabat Tujuh as a model for integrating knowledge. The circular motion model of Martabat Tujuh is expected to be used as a theoretical basis for applying knowledge integration at various Islamic universities in Indonesia.