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Background: To investigate the influence of sociodemographic factors and variables related to oral health services in oral and oropharyngeal cancer mortality in Brazil. Results: The mortality rate was higher in men than in women; the Southeast and South regions had the highest rates, which increased with age. Regarding APC analysis, men aged 57 years or more and those born from the 1920s to 1955, presented the highest mortality rate, while women born between the 1920s and the 1930s had a higher rate ratio. Kaplan-Meier survival curves and Cox regression showed that black men living in the Midwest region had the lowest survival rate. Considering the correlations, the North and Northeast regions presented mortality rates inversely proportional to FPDC and NSTB, while the Southeast presented it only to FPDC. Conclusions: The sociodemographic variables analyzed exhibited an influence on mortality and survival rates in relation to oral and oropharyngeal cancer. Regarding the oral health services, it was observed that preventive and diagnostic procedures are not being performed, which may be exacerbating the increase in the mortality rates observed.

Objective: To describe the results of a Comprehensive Medication Management (CMM) service offered to patients of an adult intensive care unit. Methods: A descriptive cross-sectional study of the results of the CMM service (April 2017 to November 2018). All the patients followed up in the CMM service were included in the sample of this study. The service was integrally based on the Pharmaceutical Care Practice and, therefore, used the Pharmacotherapy Workup (PW) method. the drug therapy Problems (DTP) were quantified and classified according to the PW method. The main medications involved in the DTP were also described, as well as the acceptance of the interventions by the multidisciplinary care team members and patients. Results: 146 patients were followed up during the study period, and 512 DTP were identified. Of these DTP, most were related to medication safety (37.7%) and to indication (37.5%). The main causes were high dose (23.0%, with emphasis on dose adjustments in cases of kidney injury), need for additional medication (18.9%, inclusion of medication for electrolytic, glycemic, and prophylactic control), and unnecessary medication (18.6%, emphasis on de-prescription of antibiotics that were not indicated). Most of the problems (23.6%) were related to the therapeutic class of systemic anti-infective agent. Of the total DTP detected, 81.6% were resolved. A total of 451 interventions were implemented, of which 92.9% (n=419) were with physicians. The majority of the interventions with physicians were accepted (n=344, 82.1%). Conclusion: A high number of drug therapy problems have been detected and resolved by the CMM pharmacist, with emphasis on safety problems. The high acceptability of the interventions reinforces the need for the service applied to the critical patient.

Dentre as ferramentas de avaliação do risco de eventos tromboembólicos, destaca-se o escore CHA 2 DS 2 -VASc, que contribui para a identificação de pacientes elegíveis ao uso da terapia anticoagulante, sendo um grande auxílio na profilaxia tromboembólica. O presente artigo objetiva caracterizar pacientes com controle inadequado da anticoagulação conforme o CHA 2 DS 2 -VASc. Foram coletadas informações dos pacientes em acompanhamento em um ambulatório de anticoagulação vinculado a um hospital de ensino em Minas Gerais. Foram incluídos pacientes acompanhados no ambulatório entre agosto e dezembro de 2017, em uso de varfarina por pelo menos 180 dias, com indicação crônica de anticoagulação e com no mínimo dois resultados do exame Relação Normatizada Internacional (RNI). Identificou-se 434 pacientes, sendo 202 com controle inadequado da anticoagulação. Para os pacientes com controle inadequado, calculouse o CHA 2 DS 2 -VASc, o qual é realizado pela somatória de pontuações de fatores de risco para eventos tromboembólicos. Os pacientes foram classificados em risco baixo (0 pontos), moderado (1 ponto) ou alto (mais de 2 pontos). Também se realizou associação entre o escore e varáveis que caracterizam o contexto dos pacientes, como município de residência e a faixa terapêutica alvo da RNI. Ressalta-se que 107 (53,0%) apresentaram hipertensão; 96 (47,5%) doença arterial periférica, coronariana ou aórtica; 62 (30,7%) acidente vascular cerebral prévio; e 27 (13,4%) diabetes. Identificou-se considerável percentual de pacientes com CHA 2 DS 2 -VASc maior que 2 (n = 191; 94,5%), o que indica um risco elevado para a ocorrência de eventos tromboembólicos e reforça a importância da farmacoterapia anticoagulante adequada. Em relação a associação entre características demográficas com os resultados de escore CHA 2 DS 2 -VASc, identificouse associação entre o escore CHA 2 DS 2 -VASc e município de residência (p<0,05), não se identificando significância estatística entre o escore CHA 2 DS 2 -VASc e a faixa terapêutica alvo da RNI (p>0,05).