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The main aim of this study is to investigate the mediator role of perceived social support in the relationship between general causality orientations and locus of control with psychopathological symptoms. Total 751 participants were consisted of 558 female ages between 17 and 36 (Female M = 19.03, SD = 0.09) (74.3%), 192 male ages between 17 and 37 (Male M = 20.71, SD = 0.17) (25.6%) and a participant who did not provide any gender information. We used the General Causality Orientations Scale (GCOS) and Locus of Control Scale (LOCS) in order to understand the basic motivation for the emergence of behavior. Beck depression Inventory (BDI) used to evaluate the psychological symptoms for depression, Maudsley Obsessive Compulsive Inventory (MOCI) for obsessive-compulsive symptomology and Brief Symptom Inventory (BSI) for overall psychological distress and finally to evaluate mediating role of social support used the Perceived Social Support Scale (PSSS). According to the results, having internal locus of control and autonomy orientation have shown positive effect to statistically significant predictors for psychological symptomology, having external locus of control and impersonal orientation have shown negative effect. Perceived social support was found to be suited for the role of partial mediator, and social support from friends was found to have more positive roles than social support from family. In conclusion, exceedingly considerable to conduct further research in order to contribute to the understanding of the mediating role of general causality orientations and locus of control with psychopathology symptomology.