Background: Constitutively active Wnt5a-Ror2 signaling in osteosarcoma cells induces MMP-13 expression. Results: MMP-13 is expressed by binding of c-Jun and ATF2 to AP1-binding sites within its promoter during Wnt5a-Ror2 signaling. Conclusion: MMP-13 expression by Wnt5a-Ror2 signaling is mediated by Dvl, Rac1, JNK, and AP1 transcription factors. Significance: This provides novel molecular machineries of Wnt5a-Ror2 signaling, involved in MMP-13 expression.
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